Instituut voor Studie van Schimmel in Menselijke Woningen

Institut pour l'Etude de Moisissure Fongique dans Habitations Humaines

Forschung Insitute für Schimmelpilze in Innenräumen

MYCOLOGICAL  INSTITUTE

for the study of

FUNGAL MOLD IN HUMAN HABITATIONS

Veterinary Therapies     Veterinary Aspergillosis     Veterinary Blastomycosis    Veterinary Treatment 1 &  2

Therapy for Canine Nasal Aspergillosis

If you care about our animal friends you may link to this page

Should Dogs be Used to Inspect for Toxic Mold?

(disease photos)     (vet notes)

Product Route Dose Interval
(hours)		 Duration
(weeks)		 Efficacy
(%)		 Reference
Thiabendazole PO* 10 mg / kg 12h 6 to 8 ± 50 Harvey 1984
Ketoconazole PO* 5 mg / kg 12h 6 to 18 ± 50 Sharp 1989
Ketoconazole PO* 5 mg / kg 12h 10 ± 60-70 Legendre 1995
Fluconazole PO* 2.5 mg / kg 12h 10 ± 60-70 Sharp 1991
Enilconazole IN1 10 mg / kg 12h 1 to 2 times ± 80 Sharp 1993
Enilconazole IN2 5 %, 50 - 200 ml 30 - 45 min infusion 1 month interval, 2 to 3 times 100 McCullough 1998
Enilconazole IN2 1% 1 hour infusion 1 month interval, 1 to 3 times up to 80% Zonderland 2000
Clotrimazole IN1 1%, once, infusion of 1 gm ± 90 Davidson 1997
Clotrimazole IN1 1%, 60 ml/side 1 hour infusion once 80 - 90 Mathews 1998
Clotrimazole IN2 1%, 60 ml/side 1 hour infusion once 80 - 90 Mathews 1998

* sometimes associated with turbinectomy

1 tubes surgically implanted

2 tubes non surgically implanted

Noninvasive intranasal infusion in dogs with nasal aspergillosis Canadian protocol.

PO = oral

IN = intranasal

         Canine and Feline Aspergillosis    

Veterinary Therapies     Veterinary Aspergillosis     Veterinary Blastomycosis    Veterinary Treatment 1 &  2

References

J.L. Zonderland, C. Clercx, J. Saunders, et al. Treatment of canine nasal aspergillosis by nonsurgically topical administration of enilconazole. Proceed. IVENTA meeting, Amsterdam, the Netherlands, April 2000.

J.P. Bray, E. Jones, R.A.S. White. Treatment of canine nasal aspergillosis with topical enilconazole. A retrospective study (1987-1996). J. Small Anim. Pract., 1998a.

J.P. Bray, R.A.S. White, B.D.X. Lascelles. Treatment of canine nasal aspergillosis with a new non-invasive technique. Failure with enilconazole. J. Small Anim. Pract., 1998b;39:223-226.

K.G. Mathews, A.P. Davidson, P.D. Koblik, et al. Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal apergillosis in dogs: 60 cases (1990-1996). J. Am. Vet. Med. Assoc., 1998;213:501-506.

S.H. Mc Cullough, B.C. McKiernan, B.S. Grodsky. Endoscopically placed tubes for administration of enilconazole for treatment of nasal aspergillosis in dogs. J. Am. Vet. Med. Assoc., 1998;212:67.

N.J.H. Sharp. Canine nasal aspergillois-penicilliosis. In: Infectious diseases of the dog and cat. Greene CE 2nd Ed.Philadelphia WB Saunders and Co, 1998:404-413.

N. Caulkett, L. Lew, C. Fries. Upper-airway obstruction and prolonged recovery from anesthesia following intranasal clotrimazole administration. J. Am. Anim. Hosp. Assoc., 1997;33:264-267.

A.P. Davidson, Mathews KG. Nasal aspergillosis: Treatment with clotrimazole. JAAHA, 1997: 33: 475

A.P. Davidson, D. Pappagianis. Treatment of nasal aspergillosis with topical clotrimazole. In Bonagura JD ed Kirk's current veterinary therapy XII small animal practice. Philadelphia WB Saunders Co, 1995;899-901.

A. Davidson, J. Komtebedde, D. Pappagianis et al. Treatment of nasal aspergillosis with topical clotrimazole (abstract). Proceed 10th Am Coll Vet Intern Med Forum 1992;807.

C.E. Harvey. Nasal aspergillosis and pencilliosis in dogs: results of treatment with thiabendazole. J. Am. Vet. Med. Assoc.,1984;184:48-50.

T. Lanthier, A. Chalifoux. Enilconazole as an adjunct to the treatment of four cases of canine nasal aspergillosis. Can. Vet. J., 1991;32:110-112.

A.M. Legendre. Antimycotic drug therapy. In Bonagura JD Ed Kirk's current veterinary therapy XII small animal practice. Philadelphia WB Saunders Co, 1995;327-331.

K.G. Mathews, P.D. Koblik, E.F. Richardson, et al. Computed tomographic assessment of noninvasive intranasal infusions in dogs with fungal rhinitis. Vet. Surg., 1996;25:309-319.

M.M. Pavletic, G.N. Clark. Open nasal cavity and frontal sinus treatment of chronic canine aspergillosis. Vet. Surg., 1991;20;1:43-48.

E.F. Richardson, K.G.Mathews. Distribution of topical agents in the frontal sinuses and nasal cavity of dogs: comparison between current protocols for treatment of nasal aspergillosis and a new noninvasive technique. Vet. Surg., 1995;24:476-483.

N.J.H. Sharp, M.H. Burrell, M. Sullivan, et al. Canine nasal aspergillosis: serology and treatment with ketoconazole. J. Small Anim. Pract., 1984;25:149-158.

N.J.H. Sharp, M. Sullivan. Use of ketoconazole in the treatment of canine nasal aspergillosis. J. Am. Vet. Med. Assoc., 1989;194:782-786.

N.J.H. Sharp. Canine nasal aspergillosis/penicilliosis. In: Greene CE, ed. Infectious diseases of the dog and cat. Philadelphia WB Saunders and Co, 1990;714-722.

N.J.H. Sharp, C.E. Harvey, J.A. O'Brien. Treatment of canine nasal aspergillosis/penicilliosis with fluconazole. J. Small Anim. Pract., 1991;32:513-516.

N.J.H. Sharp, C.E. Harvey, M. Sullivan. Canine nasal aspergillosis and penicilliosis. Compend. Contin. Educ. Pract. Vet., 1991;13:41-46.

N.J.H. Sharp, M. Sullivan. Treatment of nasal aspergillosis. In Pract., 1992;14:26-31.

N.J.H. Sharp, M. Sullivan, C.E. Harvey, et al. Treatment of nasal aspergillosis with enilconazole. J. Vet. Intern. Med., 1993;7:40-43.

Cervantes ÐOlivaries RA. PhD 1983

Lotrimin solution, Schering Plough Corp, Kenilworth, NJ

Canesten solution, Miles Canada, Etobicoke, Ont, Canada.

Clinifarm-EC, 13.8% concentrate, sterwin labs, Inc, Millsboro, DE

Imaverol, Jansen

June 13, 2000

Original site for this reference is at:

http://www.aspergillus.man.ac.uk/indexhome.htm?secure/veterinary/canine.html~main